VDJPuzzle – B-cell receptor reconstruction from single-cell RNA-seq

April 18, 2018 Leave a comment 5,000 Views

The B-cell receptor (BCR) performs essential functions for the adaptive immune system including recognition of pathogen-derived antigens. The vast repertoire and adaptive variation of BCR sequences due to V(D)J recombination and somatic...

Researchers devise a new method to study T cell heterogeneity from single cell RNA-seq data

February 17, 2016 Leave a comment 4,957 Views

Heterogeneity of T cells is a hallmark of a successful adaptive immune response, harnessing the vast diversity of antigen-specific T cells into a coordinated evolution of effector and memory outcomes. The T cell receptor (TCR) repertoire is highly diverse to ...

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VDJPuzzle – B-cell receptor reconstruction from single-cell RNA-seq

Researchers devise a new method to study T cell heterogeneity from single cell RNA-seq data

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GapClust – a light-weight approach distinguishing rare cells from voluminous single cell expression profiles

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An easy, cost-effective, and scalable method to deplete human ribosomal RNA for RNA-Seq

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A single–cell type transcriptomics map of human tissues