The genome-wide identification of microRNA transcription start sites (miRNA TSSs) is essential for understanding how miRNAs are regulated in development and disease. In this study, researchers from Vanderbilt University School of Medicine developed mirSTP (mirna transcription Start sites Tracking Program), ...
Read More »Proteome profiling outperforms transcriptome profiling for co-expression based gene function prediction
Co-expression of mRNAs under multiple conditions is commonly used to infer co-functionality of their gene products despite well-known limitations of this “guilt-by-association” (GBA) approach. Recent advancements in mass spectrometry-based proteomic technologies have enabled global expression profiling at the protein level; ...
Read More »Inconsistency of somatic SNVs called in WES and RNA-Seq data
Whole exome sequencing (WES) and RNA sequencing (RNA-Seq) are two main platforms used for next-generation sequencing (NGS). While WES is primarily for DNA variant discovery and RNA-Seq is mainly for measurement of gene expression, both can be used for detection ...
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