Published reference genomes should be re-annotated before use as references for RNA-Seq experiments

May 27, 2016 Leave a comment 8,345 Views

RNA-seq based on short reads generated by next generation sequencing technologies has become the main approach to study differential gene expression. Until now, the main applications of this technique have been to study the variation of gene expression in a ...

Modelling sample and observational level variability improves power in RNA-seq analyses

May 1, 2015 Leave a comment 5,142 Views

Variations in sample quality are frequently encountered in small RNA-sequencing experiments, and pose a major challenge in a differential expression analysis. Removal of high variation samples reduces noise, but at a cost of reducing power, thus limiting our ability to ...

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Published reference genomes should be re-annotated before use as references for RNA-Seq experiments

Modelling sample and observational level variability improves power in RNA-seq analyses

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