Study with Human Cell Atlas could help understand transmission of the virusTwo specific cell types in the nose have been identified as likely initial infection points for COVID-19 coronavirus. Scientists discovered that goblet and ciliated cells...
Read More »Single-cell RNA profiles of the human thymus over time elucidate aspects of human immunological T cell development
The thymus is the critical organ for T cell development and T cell receptor (TCR) repertoire formation, which shapes the landscape of adaptive immunity. T cell development in the thymus is spatially coordinated, and this process is orchestrated by diverse ...
Read More »Single cell RNA-Seq reveals the full life cycle of unicellular organisms
Plasmodium parasites, the causative agent of malaria, are single-celled organisms with distinct morphological developmental stages each specialized to inhabit vastly different environments...
Read More »Challenges in unsupervised clustering of single-cell RNA-seq data
Single-cell RNA sequencing (scRNA-seq) allows researchers to collect large catalogues detailing the transcriptomes of individual cells. Unsupervised clustering is of central importance for the analysis of these data, as it is used to identify putative cell types...
Read More »scmap – projection of single-cell RNA-seq data across data sets
Single-cell RNA-seq (scRNA-seq) allows researchers to define cell types on the basis of unsupervised clustering of the transcriptome. However, differences in experimental methods and computational analyses make it challenging to compare data across experiments. Wellcome Sanger Institute researchers present scmap, ...
Read More »Single-cell RNA-Seq used to create malaria cell atlas
New single-cell technology has allowed scientists to study malaria parasites at the highest resolution to date. By investigating the genes in individual malaria parasites, scientists from the Wellcome Sanger...
Read More »