Tag Archives: Wellcome Trust Sanger Institute

Using single-cell RNA-seq (scRNA-seq), the full transcriptome of individual cells can be acquired, enabling a quantitative cell-type characterisation based on expression profiles. However, due to the large variability in gene expression, identifying cell types based on the transcriptome remains challenging. ...

Mike Stubbington, PhD Senior Staff Scientist, Wellcome Trust Sanger Institute Tapio Lonnberg, PhD Postdoctoral Fellow, EMBL-EBI, Visiting Scientist at Wellcome Trust Sanger Institute DATE:  May 26, 2016 TIME:  8am pacific time, 11am eastern time Join us live and learn about ...

When cellular traits are measured using high-throughput DNA sequencing, quantitative trait loci (QTLs) manifest as fragment count differences between individuals and allelic differences within individuals. Researchers from the Wellcome Trust Sanger Institute have developed RASQUAL (Robust Allele-Specific Quantitation and Quality Control), ...

Many RNA-seq methods are excellent tools for in-depth mRNA expression analysis of small numbers of samples and provide information on the entire RNA molecule, alternative splicing and the quantity of transcript. However, they require an involved library preparation and often ...

The transcriptome of single cells can reveal important information about cellular states and heterogeneity within populations of cells. Recently, single-cell RNA-sequencing has facilitated expression profiling of large numbers of single cells in parallel. To fully exploit these data, it is ...

A vast amount of DNA variation is being identified by increasingly large-scale exome and genome sequencing projects. To be useful, variants require accurate functional annotation and a wide range of tools are available to this end. McCarthy et al recently ...

New Collaboration Between EMBL-EBI, the Wellcome Trust Sanger Institute and Fluidigm Keeps Research and Technology on the Cutting-Edge of Single-Cell Genomics December 17, 2014 06:24 AM Eastern Standard Time SOUTH SAN FRANCISCO, Calif. & HINXTON, U.K.–(BUSINESS WIRE)–A formal collaboration was ...