Tag Archives: yale university

Formalin-fixed paraffin-embedded (FFPE) tissues are the most abundant archivable specimens in clinical tissue banks, but unfortunately incompatible with single-cell level transcriptome sequencing due to RNA...

Small RNA sequencing has been widely adopted to study the diversity of extracellular RNAs (exRNAs) in biofluids; however, the analysis of exRNA samples...

Like going from a pinhole camera to a Polaroid, a significant mathematical update to the formula for a popular bioinformatics data visualization method will...

Functional genomics experiments, such as RNA-seq, provide non-individual specific information about gene expression under different conditions such as disease and normal. There is great desire to share...

RNA sequencing (RNA-seq) offers a snapshot of cellular RNA populations, but not temporal information about the sequenced RNA. Here Yale University researchers report TimeLapse-seq, which...

Date: Thursday, April 20, 2017 Time: 10:00am – 12:00pm Location: Cushing/Whitney Medical Library, Room 103 TCC, 333 Cedar St, New Haven CT 06520 Campus: Medical School Categories: Bioinformatics In Collaboration with Robert Bjornson, Ph.D, Yale Center for Research Computing This ...

Marco Onorati et al. describe the derivation and characterization, including single-cell RNA-seq, of neocortical and spinal cord neuroepithelial stem (NES) cells to model early human neurodevelopment and Zika virus (ZIKV)-related neuropathogenesis. By analyzing human NES cells, organotypic fetal brain slices, ...

Models for how lncRNAs function depend on thermodynamically stable secondary and higher-order structures that RNAs can form in the context of a cell. Probing accessible RNA bases can provide data to build models of RNA conformation that provide insight into ...

FRAMINGHAM, Mass.—SCIEX, a global leader in life science analytical technologies, today announced collaborators in the OneOmics™ project, an exclusive partnership between Illumina and SCIEX that integrates SWATH™ Acquisition based next-generation proteomics (NGP) and next-generation sequencing (NGS) data on the BaseSpace® ...

A team of Yale researchers has developed a simple method that could significantly reduce the time and cost of probing gene expression on a large scale. The findings were published March 2 in the journal Nature Methods. The team, led ...