Tag Archives: zebrafish

A team at National Taiwan University, led by Prof Shyh-Jye Lee of the Department of Life Science and director of the Research Center for Developmental Biology and Regenerative Medicine, have demonstrated that microRNAs (miRNAs) regulate the cold response of fish. ...

The immune system of vertebrate species consists of many different cell types that have distinct functional roles and are subject to different evolutionary pressures. Here, University of Lausanne and Sanger Institute researchers first analysed conservation of genes specific for all ...

To improve our understanding of pattern formation during development and disease we heavily rely on the identification of novel regulators and pathways. While RNA sequencing yields genome-wide expression data that suit this purpose, it lacks spatial resolution. Such spatial resolution ...

The transcriptional programs that govern hematopoiesis have been investigated primarily by population-level analysis of hematopoietic stem and progenitor cells, which cannot reveal the continuous nature of the differentiation process. Here researchers from the Sanger Institute-EBI applied single-cell RNA-sequencing to a ...

Chemical Watch – A team of Chinese, Singaporean and North American researchers have shown how the flame retardant tris(1,3-dichloro-2-propyl) phosphate (TDCP) affects fish livers. TDCP is widely used in plastics, textiles, varnishes, electronics equipment and furniture. It is often used ...

Recent transcriptome annotation using deep sequencing approaches have annotated a large number of long non-coding RNAs in zebrafish, a popular model organism for human diseases. These studies characterized lncRNAs in critical developmental stages as well as adult tissues. Each of ...

Spatial localization is a key determinant of cellular fate and behavior, but methods for spatially resolved, transcriptome-wide gene expression profiling across complex tissues are lacking. RNA staining methods assay only a small number of transcripts, whereas single-cell RNA-seq, which measures ...

MicroRNAs (miRs) are short non-coding RNAs that fine-tune the regulation of gene expression to coordinate a wide range of biological processes. Because of their role in the regulation of gene expression, miRs are essential players in development by acting on ...