The MOuse NOnCode Lung database

in Databases, Reader Conributions February 7, 2014 4,331 Views

The MOuse NOnCode Lung database: mouse long non-coding RNAs (lncRNA) involved in Influenza and SARS-CoV infections

The MOuse NOnCode Lung database — MONOCLdb — is an integrative and interactive database designed to retrieve and visualize annotations, expression profiles and functional enrichment results of long-non coding RNAs (lncRNAs) expressed in Collaborative Cross (http://compgen.unc.edu/) founder mice in response to respiratory infections cause by influenza and SARS-CoV viruses.

Using MONOCLdb, researchers can retrieve and visualize annotations, expression profiles and functional enrichment results of specific long-non coding RNAs. On-the-fly generation of expression heatmaps or generation of functional enrichment results (module-based enrichments, rank-based enrichments, associated GO term, associated IMMGEN module, associated REACTOME pathways) are possible using MONOCLdb. Co-expression networks and genomic networks of lncRNAs can also be visualized using MONOCLdb. Association scores between lncRNAs and pathogenicity variables are also provided by MONOCLdb. MONOCLdb also provides a Distributed Annotation System (DAS) service for visualization purposes of the non-coding genes associated with inferred biological functions (associated GO term, IMMGEN module, REACTOME pathways). Furthermore, MONOCLdb offers a web service to automatically retrieve analysis results (please see the About section for more information).