Thursday, Juy 23rd | 10 AM PDT

Longitudinal menstrual RNA-seq: a platform for studying inflammatory resolution, how it fails in disease, and enabling diagnostics.

Menstruation is one of the few recurrent, non-pathological windows into inflammatory resolution in humans. Turning that into a quantitative platform meant solving sampling at scale, library chemistry for mixed host and microbial material, and analytics that explicitly model tissue composition and cycle timing rather than filtering them away.

Featured Speaker

Stephen Gire
Co-founder & Chief Scientific Officer
NextGen Jane

You Will Learn:

• How NextGen Jane built and validated an ISO-aligned, at-home tampon collection kit that enables at-scale sampling.
• Why ribosomal-RNA depletion using Zymo’s RiboFree dsDNA-nuclease chemistry is essential for simultaneous host and microbiome transcriptomics profiling.
• How modeling tissue composition and cycle timing turns menstrual fluid into a time-resolved profile of inflammation and repair.
• How inflammatory resolution fails differently in endometriosis and autoimmune disease.
• How this framework is opening new possibilities in non-invasive diagnostics in women’s health.

Menstruation, properly modeled, becomes a quantitative human system for studying how inflammation starts and ends. That framing opens up inflammatory resolution as a measurable, dynamic process in humans, and reveals disease-specific failure modes that static snapshots of immune activation cannot see.