WaferGen Establishes Proof-of-Concept with SmartChip™-Based Single Cell RNA Sequencing Technology

FREMONT, Calif., Feb. 3, 2015 /PRNewswire/ — WaferGen Bio-systems, (NASDAQ: WGBS) announced today successful proof-of-concept of its single cell technology, which is based on the Company’s proprietary SmartChipTM platform.   WaferGen’s scientists have successfully isolated single cells and produced excellent results in downstream processing of these individual cells, including RNA sequencing.

Single cell analysis has become increasingly important for scientists attempting to unlock the underlying mechanisms of complex diseases, such as diabetes and cancer, where heterogeneous samples present a substantial challenge in understanding the molecular basis of pathological changes.  Governments and private institutions have committed significant investments toward single cell basic and clinical research, with the ultimate goal of implementing precision medicine that could transform healthcare.

It is expected that WaferGen’s SmartChipTM single cell solution will produce thousands of single cells per chip, which would be a 50-fold increase in throughput as compared to existing technologies.  In addition, the per cell cost could be a fraction of what it is today, thereby allowing researchers and clinicians to obtain substantially richer and higher quality data on their samples.  WaferGen intends to launch an Early Access Program for this technology in the second quarter of 2015.

“BGI has developed a robust system for preparing single cell genome and transcriptome sequencing libraries on a SmartChipTM, which we have found to be an ideal technology for single cell analysis,” said Dr. Xun Xu, Deputy Director and VP of R&D, BGI.  The SmartChipTM platform offers workflow simplicity, dramatically increased throughput and reduced cost.  We intend to use it in our day-to-day operations, and also offer it as a service to our customers.  We have been applying the SmartChipTM platform in a variety of applications with excellent success, and look forward to continuing our productive work with the WaferGen team.”

“The establishment of proof-of-concept for our single cell analysis technology is a significant milestone for WaferGen,” said Ivan Trifunovich, WaferGen’s President and Chief Executive Officer.  “Precision medicine is at the forefront of healthcare research, as evidenced by President Obama’s recently announced $215 million Precision Medicine Initiative, and we think our SmartChipTM platform has the potential to play an important role in this area.”

About WaferGen

WaferGen Bio-systems, Inc. is a life science company that offers innovative genomic solutions for clinical testing and research.  The SmartChip MyDesignTM Real-Time PCR System is a high-throughput genetic analysis platform for profiling and validating molecular biomarkers via microRNA and mRNA gene expression profiling, as well as single nucleotide polymorphism (SNP) genotyping.  The SmartChip TETM System is a novel product offering for target enrichment geared towards clinical Next-Gen sequencing (NGS).  The Seq-ReadyTM TE System, powered by SmartChipTM massively-parallel single plex PCR technology, is an innovative one-step target enrichment and library preparation solution. The Company now also offers the Apollo 324TM product line used in library preparation for NGS.  These three complementary technologies offer a powerful set of tools enabling more accurate, faster and cheaper genetic analysis based on Next-Gen Sequencing and Real-Time PCR.

For additional information, please see http://www.wafergen.com.

Forward Looking Statements

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